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Preformulation studies on grewia gum as a formulation excipient

Nep, Elijah I and Conway, Barbara R (2012) Preformulation studies on grewia gum as a formulation excipient. Journal of Thermal Analysis and Calorimetry, 108 (1). pp. 197-205. ISSN 1388-6150

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Abstract

Grewia gum is a naturally occurring polysaccharide which has potential as a pharmaceutical excipient. Differential scanning calorimetry and Fourier transform infrared (FT-IR) spectroscopy techniques were used to examine the thermal and molecular behaviours, respectively, of mixtures of grewia gum with cimetidine, ibuprofen or standard excipients, to assess potential interactions. No disappearance or broadening of the melting endotherm was seen with cimetidine or ibuprofen. Similarly, there was no interaction between grewia gum and the standard excipients tested. The results obtained using thermal analyses were supported by FT-IR analysis of the material mixtures. Grewia gum is an inert natural polymer which can be used alone or in combination with other excipients in the formulation of pharmaceutical dosage forms

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Sara Taylor
Date Deposited: 20 Sep 2011 12:23
Last Modified: 10 Aug 2012 09:17
URI: http://eprints.hud.ac.uk/id/eprint/11515

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