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Evaluation of grewia polysaccharide gum as a suspending agent

Nep, Elijah I and Conway, Barbara R (2011) Evaluation of grewia polysaccharide gum as a suspending agent. International Journal of Pharmacy and Pharmaceutical Sciences, 3 (2). pp. 168-173. ISSN 0975-1491

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    Grewia polysaccharide gum was extracted from the inner stem bark of Grewia mollis, thereupon drying was achieved by air‐drying (ADGG) or
    freeze‐drying (FDGG). The suspending ability of grewia gum was compared to that of xanthan (XAN), sodium carboxymethylcellulose (SCMC) and
    acacia gum (ACA) in ibuprofen suspension. The physical stability of the ibuprofen suspension formulations, containing the suspending agents at a
    range of concentrations, was assessed by appearance and pourability, viscosity and rheology, sedimentation volume ratio, redispersibility, degree of
    flocculation, zeta potential and microbial load. The ADGG and FDGG‐containing formulations exhibited pseudoplastic flow with a viscosity‐imparting
    ability superior to ACA and SCMC‐containing formulations, but not XAN, at all concentrations. ADGG‐containing formulations (1.0 %w/v) remained
    fully suspended for over 42 days while all the other formulations sedimented within 24 hours except XAN‐containing formulations. The FDGG and
    ADGG‐containing formulations were more easily redispersed than SCMC‐containing formulations and exhibited a higher degree of flocculation at
    0.75 %w/v than ACA or SCMC‐containing formulations. The zeta potential of XAN, ADGG or FDGG‐containing suspension formulations were more
    negative than ‐30 mV and therefore more stable than SCMC or ACA‐containing suspension formulations (zeta potentials of < ‐23 mV). All suspension
    formulations showed evidence of microbial growth on storage. ADGG or FDGG may provide a suitable alternative as suspending agent in
    pharmaceutical oral suspensions.

    Item Type: Article
    Subjects: Q Science > Q Science (General)
    Q Science > QD Chemistry
    Schools: School of Applied Sciences
    Related URLs:
    Depositing User: Sara Taylor
    Date Deposited: 20 Sep 2011 11:53
    Last Modified: 20 Sep 2011 11:53


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