Search:
Computing and Library Services - delivering an inspiring information environment

Cryotherapy versus salicylic acid for the treatment of plantar warts (verrucae): a randomised controlled trial

Cockayne, Sarah, Hewitt, Catherine, Hicks, Kate, Jayakody, Shalmini, Kang'ombe, Arthur Ricky, Stamuli, Eugena, Turner, Gwen, Thomas, Kim, Curran, Mike, Denby, Gary, Hashmi, Farina, McIntosh, Caroline, McLarnon, Nichola, Torgerson, David and Watt, Ian (2011) Cryotherapy versus salicylic acid for the treatment of plantar warts (verrucae): a randomised controlled trial. BMJ, 342 (07 ). p. 3271. ISSN 0959-8138

[img]
Preview
PDF - Published Version
Download (127kB) | Preview

    Abstract

    Objective: To compare the clinical effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts.
    Design: A multicentre, open, two arm randomised controlled trial.
    Setting: University podiatry school clinics, NHS podiatry clinics, and primary care in England, Scotland, and Ireland.
    Participants: 240 patients aged 12 years and over, with a plantar wart that in the opinion of the healthcare professional was suitable for treatment with both cryotherapy and salicylic acid.
    Interventions: Cryotherapy with liquid nitrogen delivered by a healthcare professional, up to four treatments two to three weeks apart. Patient self treatment with 50% salicylic acid (Verrugon) daily up to a maximum of eight weeks.
    Main outcome measures: Complete clearance of all plantar warts at 12 weeks. Secondary outcomes were (a) complete clearance of all plantar warts at 12 weeks controlling for age, whether the wart had been treated previously, and type of wart, (b) patient self reported clearance of plantar warts at six months, (c) time to clearance of plantar wart, (d) number of plantar warts at 12 weeks, and (e) patient satisfaction with the treatment.
    Results: There was no evidence of a difference between the salicylic acid and cryotherapy groups in the proportions of participants with complete clearance of all plantar warts at 12 weeks (17/119 (14%) v 15/110 (14%), difference 0.65% (95% CI –8.33 to 9.63), P=0.89).
    The results did not change when the analysis was
    repeated but with adjustment for age, whether the wart had been treated previously, and type of plantar wart or for patients’ preferences at baseline. There was no evidence of a difference between the salicylic acid and cryotherapy groups in self reported clearance of plantar warts at six months (29/95 (31%) v 33/98 (34%), difference –3.15% (–16.31 to 10.02), P=0.64) or in time to clearance (hazard ratio 0.80 (95% CI 0.51 to 1.25), P=0.33). There was also no evidence of a difference in the number of plantar warts at 12 weeks (incident rate ratio 1.08 (0.81 to 1.43), P=0.62).
    Conclusions: Salicylic acid and the cryotherapy were equally effective for clearance of plantar warts.
    Trial registration: Current Controlled Trials
    ISRCTN18994246, National Research Register
    N0484189151.

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    R Medicine > RS Pharmacy and materia medica
    Schools: School of Human and Health Sciences
    Related URLs:
    Depositing User: Cherry Edmunds
    Date Deposited: 22 Aug 2011 10:26
    Last Modified: 05 Oct 2011 15:44
    URI: http://eprints.hud.ac.uk/id/eprint/11337

    Document Downloads

    Downloader Countries

    More statistics for this item...

    Item control for Repository Staff only:

    View Item

    University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©