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Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides

Gu, Ping, Morral-Cardoner, Jordi, Wang, Jing, Rozenski, Jef, Busson, Roger, Van Aerschot, Arthur, De Clercq, Erik and Herdewijn, Piet (2003) Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides. Antivral Chemistry and Chemotherapy, 14 (1). pp. 31-37. ISSN 0956-3202

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Abstract

A series of new cyclohexenyl nucleosides is synthesized by coupling the heterocyclic bases with a protected cyclohexenyl precursor under Mitsunobu conditions. The compounds were evaluated for their antiviral and cytostatic activity. Pronounced activity against herpes simplex virus type 1 and type 2 was observed for the 2,6- diaminopurine analogue.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Sara Taylor
Date Deposited: 30 Jun 2011 10:19
Last Modified: 30 Jun 2011 10:19
URI: http://eprints.hud.ac.uk/id/eprint/10838

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