Computing and Library Services - delivering an inspiring information environment

Stem cells: The therapeutic role in the treatment of diabetes mellitus

Adams, G. G., Buttery, L., Stolnik, S., Morris, Gordon, Harding, S. and Wang, N. (2010) Stem cells: The therapeutic role in the treatment of diabetes mellitus. Biotechnology and Genetic Engineering Reviews, 27 (1). pp. 285-303. ISSN 0264-8725

Metadata only available from this repository.


The unlimited proliferative ability and plasticity to generate other cell types ensures that stem cells represent a dynamic system apposite for the identification of new molecular targets and the production and development of novel drugs. These cell lines derived from embryos could be used as a model for the study of basic and applied aspects in medical therapeutics, environmental mutagenesis and disease management. As a consequence, these can be tested for safety or to predict or anticipate potential toxicity in humans. Human ES cell lines may, therefore, prove clinically relevant to the development of safer and more effective drugs for patients presenting with diabetes mellitus.

Item Type: Article
Uncontrolled Keywords: antidiabetic agent cell line cell type diabetes mellitus embryo development human mutagenesis nonhuman organogenesis review stem cell treatment indication
Subjects: R Medicine > RM Therapeutics. Pharmacology
Schools: School of Applied Sciences
Related URLs:

Language of Original Document: English
Correspondence Address: Adams, G. G.; University of Nottingham, Faculty of Medicine and Health Sciences, Insulin Diabetes Experimental Research Group, Clifton Boulevard, Nottingham NG7 2RD, United Kingdom; email:
References: Ahuja, Y.R., Vijayalakshmi, V., Stem cell test: A practical tool in toxicogenomics (2007) Toxicology, 231 (1), pp. 1-10; Ainsworth, C.D., Crowther, M.A., Treleaven, D., Evanovttch, D., Webert, K.E., Blajchman, M.A., Severe hemolytic anemia post-renal transplantation produced by donor anti-D passenger lymphocytes, case report and literature review (2009) Transfusion Medical Review, 23 (2), pp. 155-159; Amit, M., Carpenter, M.K., Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture (2000) Developmental Biology, 227 (2), pp. 271-278; Amit, M., Itskovitz-Eldor, J., Maintenance of human embryonic stem cells in animal serum- and feeder layer-free culture conditions (2006) Methods Molecular Biology, 331, pp. 105-113; Amit, M., Margulets, V., Human feeder layers for human embryonic stem cells (2003) Biological Reproduction, 68 (6), pp. 2150-2156; Andrews, P.W., From teratocarcinomas to embryonic stem cells (2002) Philosophical Transactions of the Royal Society B, 357 (1420), pp. 405-417; Armstrong, L., Lako, M., mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells (2000) Mechanisms of Development, 97 (1-2), pp. 109-116; Axelrod, H.R., Embryonic stem cell lines derived from blastocysts by a simplified technique (1984) Developmental Biology, 101 (1), pp. 225-228; Bjornson, C.R., Rietze, R.L., Turning brain into blood, a hematopoietic fate adopted by adult neural stem cells in vivo (1999) Science, 283 (5401), pp. 534-537; Blyszczuk, P., A, C., Rozzo, A., Kania, G., St-Onge, L., Rupnik, M., Wobus, A.M., Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells (2004) International Journal of Developmental Biology, 48 (10), pp. 1095-1104; Blyszczuk, P., Wobus, A.M., In vitro differentiation of embryonic stem cells into the pancreatic lineage (2006) Methods Molecular Biology, 330, pp. 373-385; Boheler, K.R., Czyz, J., Differentiation of pluripotent embryonic stem cells into cardiomyocytes (2002) Circulation Research, 91 (3), pp. 189-201; Brenin, D., Look, J., Rat embryonic stem cells, a progress report (1997) Transplantion Proceedings, 29 (3), pp. 1761-1765; Bukovsky, A., Caudle, M.R., Virant-Klun, I., Gupta, S.K., Dominguez, R., Svetlikova, M., Xu, F., Immune physiology and oogenesis in fetal and adult humans, ovarian infertility, and totipotency of adult ovarian stem cells (2009) Birth Defects Research C Embryo Today, 87 (1), pp. 64-89; Burdon, T., Chambers, I., Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells (1999) Cells Tissues Organs, 165 (3-4), pp. 131-143; Burdon, T., Stracey, C., Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells (1999) Developmental Biology, 210 (1), pp. 30-43; Cameron, C.M., Hu, W.S., Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation (2006) Biotechnology Bioengineering, 94 (5), pp. 938-948; Cameron, C.M., Hu, W.S., Kaufman, D.S., Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation (2006) Biotechnology and Bioengineering, 94 (5), pp. 938-948; Chambers, I., Colby, D., Functional expression cloning of Nanog, apluripotency sustaining factor in embryonic stem cells (2003) Cell, 113 (5), pp. 643-655; Chang, I.K., Jeong, D.K., Production of germline chimeric chickens by transfer of cultured primordial germ cells (1997) Cell Biology International, 21 (8), pp. 495-499; Chugh, A.R., Zuba-Surma, E.K., Dawn, B., Bone marrow-derived mesenchymal stems cells and cardiac repair (2009) Minerva Cardioangiologica, 57 (2), pp. 185-202; Daheron, L., Opitz, S.L., LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells (2004) Stem Cells, 22 (5), pp. 770-778; Dang, S.M., Kyba, M., Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems (2002) Biotechnology Bioengineering, 78 (4), pp. 442-453; Dang, S.M., Zandstra, P.W., Scalable production of embryonic stem cell-derived cells (2005) Methods Molecular Biology, 290, pp. 353-364; Davila, J.C., Cezar, G.G., Use and application of stem cells in toxicology (2004) Toxicology Science, 79 (2), pp. 214-223; De Coppi, P., Bartsch Jr., G., Isolation of amniotic stem cell lines with potential for therapy (2007) Nature Biotechnology, 25 (1), pp. 100-106; Dessimoz, J., Opoka, R., FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo (2006) Mechanisms of Development, 123 (1), pp. 42-55; Doetschman, T., Williams, P., Establishment of hamster blastocyst-derived embryonic stem (ES) cells (1988) Developmental Biology, 127 (1), pp. 224-227; Doetschman, T.C., Eistetter, H., The in vitro development of blastocyst-derived embryonic stem cell lines, formation of visceral yolk sac, blood islands and myocardium (1985) Journal of Embryological Experimental Morphology, 87, pp. 27-45; Doss, M.X., K, C., Gissel, C., Hescheler, J., Sachinidis, A., Embryonic stem cells, a promising tool for cell replacement therapy (2004) Journal of Cell Molecular Medicine, 8 (4), pp. 465-473; Esni, F., Ghosh, B., Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas (2004) Development, 131 (17), pp. 4213-4224; Evans, M.J., Kaufman, M.H., Establishment in Culture of Pluripotential Cells from Mouse Embryos (1981) Nature, 292 (5819), pp. 154-156; Ezhkova, E., Pasolli, H.A., Parker, J.S., Stokes, N., Su, I.H., Hannon, G., Tarakhovsky, A., Fuchs, E., Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells (2009) Cell, 136 (6), pp. 1122-1135; Gearhart, J.D., Mintz, B., Contact-mediated myogenesis and increased acetylcholinesterase activity in primary cultures of mouse teratocarcinoma cells (1974) Proceedings National Academy of Sciences U S A, 71 (5), pp. 1734-1738; Geijsen, N., Horoschak, M., Derivation of embryonic germ cells and male gametes from embryonic stem cells (2004) Nature, 427 (6970), pp. 148-154; Gittes, G.K., Galante, P.E., Lineage-specific morphogenesis in the developing pancreas, Role of mesenchymal factors (1996) Development, 122 (2), pp. 439-447; Golosow, N., Grobstein, C., Epitheliomesenchymal Interaction in Pancreatic Morphogenesis (1962) Developmental Biology, 4 (2), p. 242; Graves, K.H., Moreadith, R.W., Derivation and characterization of putative pluripotential embryonic stem cells from preimplantation rabbit embryos (1993) Molecular Reproductive Development, 36 (4), pp. 424-433; Gupta, S., Chowdhury, J.R., Therapeutic potential of hepatocyte transplantation (2002) Seminars in Cell & Developmental Biology, 13 (6), pp. 439-446; Hart, A., Papadopoulou, S., Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells (2003) Developmental Dynamics, 228 (2), pp. 185-193; Heiser, P.W., Lau, J., Stabilization of beta-catenin impacts pancreas growth (2006) Development, 133 (10), pp. 2023-2032; Holtzer, H., Cell lineages, stem cells and the quantal cell cycle concept (1978) Stem Cells and Tissue Homeostasis, , Cambridge University Press; Hu, A., Cai, J., Zheng, Q., He, X., Pan, Y., Li, L., Hepatic differentiation from embryonic stem cells in vitro (2003) Chinese Medicine Journal (Engl), 116 (12), pp. 1893-1897; Hubner, K., Fuhrmann, G., Derivation of oocytes from mouse embryonic stem cells (2003) Science, 300 (5623), pp. 1251-1256; Jakob, H., Boon, T., Teratocarcinoma of the mouse, isolation, culture and properties of pluripotential cells (1973) Annals of Microbiology, 124 (3), pp. 269-282. , Paris; Kalkunte, S.S., Mselle, T.F., Norris, W.E., Wira, C.R., Sentman, C.L., Sharma, S., Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface (2009) Journal of Immunology, 182 (7), pp. 4085-4092; Kroon, E., Martinson, L.A., Kadoya, K., Bang, A.G., Kelly, O.G., Eliazer, S., Young, H., Cunningham, J., Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo (2008) Nature Biotechnology, 26, pp. 443-452; Kurosawa, H., Methods for inducing embryoid body formation, in vitro differentiation system of embryonic stem cells (2007) Journal of Bioscience and Bioengineering, 103 (5), pp. 389-398; Labosky, P.A., Barlow, D.P., Mouse Embryonic Germ (Eg) Cell-Lines - Transmission through the Germline and Differences in the Methylation Imprint of Insulin-Like Growth-Factor 2 Receptor (Igf2R) Gene Compared with Embryonic Stem (Es) Cell-Lines (1994) Development, 120 (11), pp. 3197-3204; Lee, J.B., Lee, J.E., Establishment and maintenance of human embryonic stem cell lines on human feeder cells derived from uterine endometrium under serum-free condition (2005) Biological Reproduction, 72 (1), pp. 42-49; Lester, L.B., K, H., Andrews, L., Nauert, B., Wolf, D.P., Directed differentiation of rhesus monkey ES cells into pancreatic cell phenotypes (2004) Reproductive Biological Endocrinology, 16, p. 42; Lewis, S.L., Tam, P.P., Definitive endoderm of the mouse embryo, formation, cell fates, and morphogenetic function (2006) Developmental Dynamics, 235 (9), pp. 2315-2329; Lumelsky, N., Blondel, O., Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets (2001) Science, 292 (5520), pp. 1389-1394; Maguire, T., Novik, E., Schloss, R., Yarmush, M., Alginate-PLL microencapsulation, effect on the differentiation of embryonic stem cells into hepatocytes (2006) Biotechnology Bioengineering, 93 (3), pp. 581-591; Martin, G.R., Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells (1981) Proceedings National Academy of Sciences U S A, 78 (12), pp. 7634-7638; Matsui, Y., Zsebo, K., Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture (1992) Cell, 70 (5), pp. 841-847; Meirelles, L., Nardi, N.B., Methodology, biology and clinical applications of mesenchymal stem cells (2009) Frontiers in Bioscience, 14, pp. 4281-4298; Miettinen, P.J., Huotari, M.A., Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors (2000) Development, 127 (12), pp. 2617-2627; Mimeault, M., Batra, S.K., Concise review, recent advances on the significance of stem cells in tissue regeneration and cancer therapies (2006) Stem Cells, 24 (11), pp. 2319-2345; Miralles, F., Czernichow, P., Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development (1998) Development, 125 (6), pp. 1017-1024; Mitsui, K., Tokuzawa, Y., The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells (2003) Cell, 113 (5), pp. 631-642; Miyazaki, S., Yamato, E., Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells (2004) Diabetes, 53 (4), pp. 1030-1037; Murtaugh, L.C., Law, A.C., Beta-Catenin is essential for pancreatic acinar but not islet development (2005) Development, 132 (21), pp. 4663-4674; Niwa, H., Burdon, T., Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3 (1998) Genes Development, 12 (13), pp. 2048-2060; Niwa, H., Miyazaki, J., Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells (2000) Nature Genetics, 24 (4), pp. 372-376; Norgaard, G.A., Jensen, J.N., FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development (2003) Developmental Biology, 264 (2), pp. 323-338; Odorico, J.S., Kaufman, D.S., Multilineage differentiation from human embryonic stem cell lines (2001) Stem Cells, 19 (3), pp. 193-204; Oktem, O., Oktay, K., Current knowledge in the renewal capability of germ cells in the adult ovary (2009) Birth Defects Research C Embryo Today, 87 (1), pp. 90-95; Papadopoulou, S., Edlund, H., Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function (2005) Diabetes, 54 (10), pp. 2844-2851; Parrish, Y.K., Baez, I., Milford, T.A., Benitez, A., Galloway, N., Rogerio, J.W., Sahakian, E., Payne, K.J., IL-7 Dependence in human B lymphopoiesis increases during progression of ontogeny from cord blood to bone marrow (2009) Journal of Immunology, 182 (7), pp. 4255-4266; Pau, K.Y., Wolf, D.P., Derivation and characterization of monkey embryonic stem cells (2004) Reproductive Biological Endocrinology, 2, p. 41; Pesce, M., Anastassiadis, K., Oct-4, lessons of totipotency from embryonic stem cells (1999) Cells Tissues Organs, 165 (3-4), pp. 144-152; Pieler, T., Chen, Y., Forgotten and novel aspects in pancreas development (2006) Biol Cell, 98 (2), pp. 79-88; Prelle, K., Vassiliev, I.M., Establishment of pluripotent cell lines from vertebrate species-present status and future prospects (1999) Cells Tissues Organs, 165 (3-4), pp. 220-236; Prockop, D.J., Marrow stromal cells as stem cells for nonhematopoietic tissues (1997) Science, 276 (5309), pp. 71-74; Qu, X.B., Pan, J., Zhang, C., Huang, S.Y., Sox17 facilitates the differentiation of mouse embryonic stem cells into primitive and definitive endoderm in vitro (2008) Developmental Growth and Differentiation, 50 (7), pp. 585-593; Rahier, J., (1988) The Diabetic Pancreas, a Pathologist's View, , New York, Springer-Verlag; Resnick, J.L., Bixler, L.S., Long-Term Proliferation of Mouse Primordial Germ-Cells in Culture (1992) Nature, 359 (6395), pp. 550-551; Reubinoff, B.E., Pera, M.F., Embryonic stem cell lines from human blastocysts, somatic differentiation in vitro (2000) Nature Biotechnology, 18 (4), pp. 399-404; Reynolds, B.A., Weiss, S., Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system (1992) Science, 255 (5052), pp. 1707-1710; Richards, M., Fong, C.Y., Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells (2002) Nature Biotechnology, 20 (9), pp. 933-936; Robertson, E., Embryo-derived stem cell lines (1987) Teratocarcinoma and Embryonic Stem Cells, a Practical Approach, , Oxford, UK, IRL; Sasaki, E., Hanazawa, K., Establishment of novel embryonic stem cell lines derived from the common marmoset (Callithrix jacchus) (2005) Stem Cells, 23 (9), pp. 1304-1313; Sato, N., Meijer, L., Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor (2004) Nature Medicine, 10 (1), pp. 55-63; Scholer, H.R., Hatzopoulos, A.K., A family of octamer-specific proteins present during mouse embryogenesis, evidence for germline-specific expression of an Oct factor (1989) Embo Journal, 8 (9), pp. 2543-2550; Schoonjans, L., Albright, G.M., Pluripotential rabbit embryonic stem (ES) cells are capable of forming overt coat color chimeras following injection into blastocysts (1996) Molecular Reproductive Development, 45 (4), pp. 439-443; Serakinci, N., Keith, W.N., Therapeutic potential of adult stem cells (2006) European Journal of Cancer, 42 (9), pp. 1243-1246; Shamblott, M.J., Axelman, J., Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro (2001) Proceedings of the National Academy of Sciences U S A, 98 (1), pp. 113-118; Shiraki, N., Higuchi, Y., Harada, S., Umeda, K., Isagawa, T., Aburatani, H., Kume, K., Kume, S., Differentiation and characterization of embryonic stem cells into three germ layers (2009) Biochemical and Biophysical Research Communications, pp. 278-283; Shiroi, A., Yoshikawa, M., Identification of insulin-producing cells derived from embryonic stem cells by zinc-chelating dithizone (2002) Stem Cell

Depositing User: Gordon Morris
Date Deposited: 19 May 2011 11:33
Last Modified: 01 Jul 2011 14:13


Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©