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Molecular flexibility of methylcelluloses of differing degree of substitution by combined sedimentation and viscosity analysis

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Patel, T. R., Morris, Gordon, Garcia de la Torre, J., Ortega, A., Mischnick, P. and Harding, S. E. (2008) Molecular flexibility of methylcelluloses of differing degree of substitution by combined sedimentation and viscosity analysis. Macromolecular Bioscience, 8 (12). pp. 1108-1115. ISSN 1616-5187

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Abstract

The flexibility/rigidity of methylcelluloses (MCs) plays an important part in their structure-function relationship and therefore on their commercial applications in the food and biomedical industries. In the present study, two MCs of low degree of substitution (DS) 1.09 and 1.32 and four of high DS (1.80, 1.86, 1.88 and 1.93) were characterised in distilled water in terms of intrinsic viscosity [η]; sedimentation coefficient (s20,w0) and weight average molar mass (M̄w). Solution conformation and flexibility were estimated qualitatively using conformation zoning and quantitatively (persistence length Lp) using the new combined global method. Sedimentation conformation zoning showed an extended coil (Type C) conformation and the global method applied to each MC sample yielded persistence lengths all within the range Lp = 12-17 nm (for a fixed mass per unit length) with no evidence of any significant change in flexibility with DS. A graph is presented. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Item Type: Article
Uncontrolled Keywords: Conformational analysis Intrinsic viscosity Methylcellulose Molar mass Persistence length Sedimentation coefficient Dielectric relaxation Land use Sedimentation Viscosity Zoning Conformations article chemistry conformation high performance liquid chromatography molecular weight structure activity relation ultracentrifugation Chromatography, High Pressure Liquid Molecular Conformation Structure-Activity Relationship
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
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Language of Original Document: English
Correspondence Address: Harding, S.E.; National Center for Macromolecular Hydrodynamics, School of Biosciences, University of Nottingham, Sutton Bonington LE12 5RD, United Kingdom; email: steve.harding@nottingham.ac.uk
Chemicals/CAS: methylcellulose, 79484-92-7, 9004-67-5; Methylcellulose, 9004-67-5
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Depositing User: Gordon Morris
Date Deposited: 20 May 2011 10:32
Last Modified: 01 Jul 2011 15:41
URI: http://eprints.hud.ac.uk/id/eprint/10451

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