Koschella, A., Inngjerdingen, K., Paulsen, B. S., Morris, Gordon, Harding, S. E. and Heinze, T. (2008) Unconventional methyl galactan synthesized via the thexyldimethylsilyl intermediate: Preparation, characterization, and properties. Macromolecular Bioscience, 8 (1). pp. 96-105. ISSN 1616-5187Metadata only available from this repository.
Reaction of a Î²-(1 â†’ 4) linked galactan with TDMS chloride followed by methylation and desilylation yields methyl galactans with unconventional functionalization patterns. The products were characterized via FTIR and NMR of the intact polymer and by CE after controlled depolymerization. A TDMS-derivatized methyl galactan contains differently methylated secondary hydroxyl groups. SEC and analytical ultracentrifugation showed a consistent decrease in the molecular weight after the consecutive reaction steps. Biological studies revealed that the methyl galactans are less active in complement fixation assays as compared with a 3-O-methyl galactan-enriched polysaccharide fraction isolated from Acanthus ebracteatus. (Graph Presented) Â© 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
|Uncontrolled Keywords:||Î²-(1 â†’ 4) galactan Biological activity Biopolymers NMR Thexyldimethylsilyl ether Methyl galactan Ultracentrifugation Bioactivity Depolymerization Fourier transform infrared spectroscopy Molecular weight Nuclear magnetic resonance Ethers 3 o methylgalactan galactan methylgalactan polysaccharide unclassified drug Acanthus ebracteatus article carbohydrate synthesis desilylation fractionation infrared spectroscopy medicinal plant methylation nonhuman nuclear magnetic resonance spectroscopy Complement Fixation Tests Galactans Magnetic Resonance Spectroscopy Methylgalactosides Models, Molecular Molecular Structure Spectroscopy, Fourier Transform Infrared|
|Subjects:||Q Science > QD Chemistry|
|Schools:||School of Applied Sciences|
Language of Original Document: English
|Depositing User:||Gordon Morris|
|Date Deposited:||13 May 2011 11:32|
|Last Modified:||01 Jul 2011 15:38|
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