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Grewia polysaccharide as a pharmaceutical excipient in matrix tablets

Nep, E.I. and Conway, Barbara R (2011) Grewia polysaccharide as a pharmaceutical excipient in matrix tablets. Journal of Excipients and Food Chemicals, 2 (1). pp. 3-15. ISSN 2150-2668

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    Abstract

    Matrix-based tablets using different concentrations of grewia gum, and the model drug ibuprofen, were
    prepared using a wet granulation technique. Similar formulations were also prepared using HPMC, guar gum
    or ethyl cellulose as the polymer matrix. In addition to tablet properties, swelling and erosion of tablets and
    kinetics of drug release were also investigated. In vitro drug release studies, in phosphate buffer (pH 7.2) using
    USP type II apparatus, revealed that grewia gum at concentrations of 16%, 32% and 48% can sustain the
    release of ibuprofen tablets for up to 24 hours. Release profiles were similar to those tablets containing ethyl
    cellulose as the matrix former. Swelling and erosion of grewia gum matrices occurred simultaneously, and
    ibuprofen release was by anomalous diffusion in accordance with the Korsmeyer-Peppas model. There was
    evidence suggesting synergism between grewia gum and guar gum in sustaining the release of ibuprofen from
    tablets when used in the ratio 2:1. Grewia gum may therefore prove a useful excipient, when used on its own,
    or in combination with other polymers, to modify drug release

    Item Type: Article
    Uncontrolled Keywords: Ibuprofen, swelling, erosion, drug release, release profile, controlled delivery
    Subjects: Q Science > Q Science (General)
    Q Science > QD Chemistry
    Schools: School of Applied Sciences
    Related URLs:
    Depositing User: Sara Taylor
    Date Deposited: 14 Apr 2011 16:43
    Last Modified: 14 Apr 2011 16:43
    URI: http://eprints.hud.ac.uk/id/eprint/10144

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