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Polysaccharide gum matrix tablets for oral controlled delivery of Cimetidine

Nep, E.I. and Conway, Barbara R (2010) Polysaccharide gum matrix tablets for oral controlled delivery of Cimetidine. Journal of Pharmaceutical Sciences and Research, 2 (11). pp. 708-716. ISSN 0975-1459

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    Matrix-based tablets using 40 %w/w grewia gum were prepared by direct compression to contain
    cimetidine as novel drug. The formulations were compared with similar formulations using
    hydroxypropyl methylcelluose (Methocel®), gum arabic, carboxy methylcellulose (Blanose®), or
    ethyl cellulose (Ethocel®) as polymer matrix. Also binary composite matrices containing grewia
    gum and the reference polymers (40 %w/w total polymer concentration in a ratio of 1:1) were
    directly compressed. In addition to tablet properties, swelling, erosion, kinetics of drug release from
    the matrices and stability of the tablet formulations were also investigated. In vitro drug release
    studies reveal that grewia gum can control the release of cimetidine from tablets for up to 12 hours.
    This strong sustained-release potential of grewia polysaccharide gum was superior to hydrophilic
    matrices of hydroxypropyl methylcellulose, carboxy methylcellulose and gum arabic. The release
    of drug from the grewia polysaccharide gum matrices follows Higuchi kinetic models. There was
    synergy between grewia gum and HPMC in delaying the release of cimetidine from tablets. Grewia
    gum may therefore prove a useful excipient when used alone, or in combination with other
    polymers to modify the release of soluble drugs from polymeric matrices

    Item Type: Article
    Uncontrolled Keywords: Grewia gum, cimetidine, matrix tablets, controlled delivery.
    Subjects: Q Science > Q Science (General)
    Q Science > QD Chemistry
    Schools: School of Applied Sciences
    Related URLs:
    Depositing User: Sara Taylor
    Date Deposited: 14 Apr 2011 16:29
    Last Modified: 14 Apr 2011 16:29


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